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. 2019 Mar 5;10:208. doi: 10.3389/fphys.2019.00208

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Copyright © 2019 Lock, Darby, Soo, Brooks, Perumal, Selvanayagam, Seed, Macgowan, Porrello, Tellam and Morrison.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression of inflammatory cytokines in sheep 3 days post-MI. Mean normalized expression (MNE) of TNFA (A), IL6 (B), IL1β (C) and BCL2 (D) in Sham, Remote, Border, and Infarct Tissue. Superscript letters (Fetal Sheep; a, b, c and Adolescent Sheep; x, y, z) represent significance between tissue regions (Remote, Border, and Infarct) at each age (P < 0.05). ^∗represents significantly different data from the sham animals at each age (P < 0.05). Analyses between tissue regions (Infarct vs. Border vs. Remote) at each age were assessed using a nested Analysis of variance (ANOVA). A Bonferroni post hoc test was performed with multiple comparisons for each tissue region against the Sham tissue. n = 5 per treatment group per age.