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. 2019 Feb 13;47(5):2487–2505. doi: 10.1093/nar/gkz086

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Schematic diagram of pre-mRNA splicing. (A) Schematic model of pre-mRNA splicing. U1, U1 snRNP; U2, U2 snRNP; U4, U4 snRNP; U5, U5 snRNP; and U6, U6 snRNP. IIa, stem IIa form of U2 snRNA; IIc, stem IIc form of human U2 snRNA (see Figure 7C). First step; first esterification reaction, second step; second esterification reaction. (B) Proposed four-helix (left) and three-helix (right) junction structures of human U2 snRNA in the U2−U6 snRNA complex. The structures are drawn based on yeast U2 snRNA models (65,74). 2′-O-methylated 12G and 19G are shown in red letters. (C) Structures of stem IIa and stem IIc forms of human U2 snRNA. The structures are drawn based on the proposed structures of yeast U2 snRNA (76). 2′-O-methylated 47U and 61C are shown in red letters.