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. 2019 Jan 30;47(5):2446–2454. doi: 10.1093/nar/gkz030

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Gene expression by location on the chromosome. (A) The y-ome genes are enriched in the termination region of the E. coli chromosome, opposite the ORI. However, the y-ome genes in the top 20th percentile of expression (mean log-TPM > 7.57) are enriched both near the ORI and the termination region. (B) Highly expressed genes are known to be enriched around the ORI (16), which we confirmed by plotting density of genes in the chromosome with increasing thresholds of mean gene expression (mean log-TPM) across the compendium of RNA-seq data for 78 conditions.