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. 2019 Jan 3;40:643–654. doi: 10.1016/j.ebiom.2018.12.059

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© 2018 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — CORM-3 inhibit pyroptosis and inflammasomes signaling at 3 days after SCI.

(A) The mRNA expression of caspase1, IL-1β and IL-18 of each group at early time points after SCI. (B) Double immunofluorescence of cleaved-caspase1 and NeuN in sections from tissue at 3 day after SCI (bar: 50 μm) (C) and (D) The protein expression of GSDMD, cleaved-caspase1, cleaved-caspase11, IL-1β and IL-18 in spinal cord at 3 days after SCI. (E) The ELISA of IL-1β and IL-18 at 3 days after SCI. (F) The mRNA expression of NLRP1 and NLRP3 of each group at early time points after SCI. (F) and (G) The protein expression of NLRP1 and NLRP3 in spinal cord at 3 days after SCI. All data represent mean ± S.D. (n = 5) **P < .01.