Table 1.

Favorable and unfavorable survival and prognostic genes in HCC involved in redox metabolism. Significantly altered redox genes between 50 high vs 50 bottom survival subjects are displayed, where fold changes > 1 indicate an upregulated gene among the poor survival group, and prognostic genes in liver cancer [27] are shown. Favorable and unfavorable prognostic genes are those respectively up- and downregulated in the high survival group. CAT was identified as a prognostic gene in liver cancer in agreement with its expression variation between survival groups, despite being marginally not statistically differentially expressed.

Module	Gene	Fold Change	P value	Q value	Prognostic genes
General ROSresponse	SQSTM1	1.74	0.00032	0.0065	Unfavorable
	HIF1A	1.49	0.0026	0.026	Unfavorable
	FOXO1	0.56	9.8 × 10−7	0.00012	Favorable
Catalase	CAT	0.72	0.0074	0.052	Favorable
Glutathione	GSR	1.44	0.0006	0.01	Unfavorable
	GCLM	1.52	0.0022	0.024	Unfavorable
	GGT5	0.5	0.0002	0.0048	Favorable
	GSTK1	0.75	0.0051	0.041	Favorable
	GSTO1	0.71	0.0055	0.043	Favorable
Thioredoxin	TXNRD1	1.94	8.1 × 10−6	0.00049	Unfavorable
	TXNDC11	0.77	0.00099	0.014	Favorable
NAD(P)H	ALDH2	0.62	0.00064	0.01	Favorable
	ME1	1.27	0.0059	0.045	Unfavorable
	G6PD	2.68	4.9 × 10−9	2.6 × 10−6	Unfavorable
	NNT	0.62	0.00027	0.0059	Favorable
	ALDH5A1	0.68	0.0043	0.036	Favorable
PPP	RPIA	1.26	0.0023	0.024	Unfavorable
	GPI	0.72	0.0037	0.033	Favorable
	PGM1	0.74	0.0045	0.038	Favorable
Folate	FPGS	0.73	0.00182	0.021	Favorable
	MTHFS	0.62	0.00013	0.0037	Favorable
	GART	1.19	0.005	0.04	Unfavorable
Amino acid metabolism	SHMT1	0.63	0.0034	0.032	Favorable
	XCT	2.05	0.00075	0.012	Unfavorable
Glycolysis	ALDOB	0.45	0.0001	0.003	Favorable
	PFKP	1.96	0.00028	0.006	Unfavorable