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. 2019 Jan 25;11(2):267. doi: 10.3390/nu11020267

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of rosmarinic acid on the serum concentration of estradiol and progesterone in ovariectomized rats. Rosmarinic acid at doses of 10 mg/kg (OVX + RA10) and 50 mg/kg (OVX + RA50) was administered orally to ovariectomized rats, once daily for 28 days. SHAM: sham-operated control rats; OVX: ovariectomized control rats. Results are presented as the mean ± SEM. One-way ANOVA followed by Fisher’s LSD test were used for evaluation of the significance of the results. ** p < 0.01, *** p < 0.001: significantly different from the SHAM control rats.