Table 1.
Effect of rosmarinic acid on the serum activity of antioxidative enzymes and concentrations of oxidative damage markers in ovariectomized rats.
| Parameter/Group | SHAM | OVX | OVX + RA10 | OVX + RA50 |
|---|---|---|---|---|
| SOD (U/mg of protein) | 5.22 ± 0.19 | 6.20 ± 0.34 * | 6.39 ± 0.35 ** | 6.21 ± 0.27 * |
| CAT (nmol/min/mg of protein) | 0.52 ± 0.08 | 0.74 ± 0.19 | 0.74 ± 0.14 | 0.91 ± 0.25 |
| TBARS (nmol/mL) | 21.5 ± 1.9 | 24.1 ± 1.9 | 19.1 ± 0.7 | 19.9 ± 1.1 |
| AOPP (nmol/mL) | 19.9 ± 1.2 | 25.0 ± 4.4 | 16.9 ± 2.0 # | 13.6 ± 2.2 ## |
| PCG (nmol/mL) | 5.52 ± 0.40 | 5.87 ± 0.85 | 5.16 ± 0.44 | 5.00 ± 0.95 |
Rosmarinic acid at doses of 10 mg/kg (OVX + RA10) and 50 mg/kg (OVX + RA50) was administered orally to ovariectomized rats, once daily for 28 days. SHAM: sham-operated control rats; OVX: ovariectomized control rats; SOD: superoxide dismutase; CAT: catalase; TBARS: thiobarbituric acid reactive substances; AOPP: advanced oxidation protein products; PCG: protein carbonyl groups. Results are presented as the mean ± SEM. The concentration of AOPP is presented in chloramine T equivalents. One-way ANOVA followed by Fisher’s LSD test was used for evaluation of the significance of the results. * p <0.05, ** p <0.01: significantly different from the SHAM control rats. # p <0.05, ## p <0.01—significantly different from the OVX control rats.