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. 2019 Jan 25;11(2):267. doi: 10.3390/nu11020267

Table 1.

Effect of rosmarinic acid on the serum activity of antioxidative enzymes and concentrations of oxidative damage markers in ovariectomized rats.

Parameter/Group SHAM OVX OVX + RA10 OVX + RA50
SOD (U/mg of protein) 5.22 ± 0.19 6.20 ± 0.34 * 6.39 ± 0.35 ** 6.21 ± 0.27 *
CAT (nmol/min/mg of protein) 0.52 ± 0.08 0.74 ± 0.19 0.74 ± 0.14 0.91 ± 0.25
TBARS (nmol/mL) 21.5 ± 1.9 24.1 ± 1.9 19.1 ± 0.7 19.9 ± 1.1
AOPP (nmol/mL) 19.9 ± 1.2 25.0 ± 4.4 16.9 ± 2.0 # 13.6 ± 2.2 ##
PCG (nmol/mL) 5.52 ± 0.40 5.87 ± 0.85 5.16 ± 0.44 5.00 ± 0.95

Rosmarinic acid at doses of 10 mg/kg (OVX + RA10) and 50 mg/kg (OVX + RA50) was administered orally to ovariectomized rats, once daily for 28 days. SHAM: sham-operated control rats; OVX: ovariectomized control rats; SOD: superoxide dismutase; CAT: catalase; TBARS: thiobarbituric acid reactive substances; AOPP: advanced oxidation protein products; PCG: protein carbonyl groups. Results are presented as the mean ± SEM. The concentration of AOPP is presented in chloramine T equivalents. One-way ANOVA followed by Fisher’s LSD test was used for evaluation of the significance of the results. * p <0.05, ** p <0.01: significantly different from the SHAM control rats. # p <0.05, ## p <0.01—significantly different from the OVX control rats.