Table 2.

Effect of rosmarinic acid on the serum concentration of interleukin 18, and activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in ovariectomized rats.

Parameter/Group	SHAM	OVX	OVX + RA10	OVX + RA50
Interleukin 18 (pg/mL)	312.0 ± 13.7	235.0 ± 22.7	298.0 ± 27.3	315.9 ± 33.5
AST (U/L)	39.22 ± 3.38	34.72 ± 2.78	37.60 ± 3.57	41.61 ± 2.57
ALT (U/L)	23.68 ± 2.19	23.52 ± 1.38	25.20 ± 1.86	30.65 ± 3.84

Rosmarinic acid at doses of 10 mg/kg (OVX+RA10) and 50 mg/kg (OVX+RA50) was administered orally to rats, once daily for 28 days. SHAM: sham-operated control rats; OVX: ovariectomized control rats. Results are presented as the mean ± SEM. One-way ANOVA followed by Fisher’s LSD test were used for evaluation of the significance of the results.