Scheme 1.
Reagents and conditions: (a) zinc dust, concentrated HCl, dioxane, r.t.; (b) CH3I, K2CO3, DMF, r.t.; (c) Jones reagent, acetone, 0 °C; (d) ethyl formate, NaOMe, benzene, r.t., N2; and (e) CDI, CBMI or CDT, dry THF, reflux, N2.
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