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. 2019 Feb 22;20(4):959. doi: 10.3390/ijms20040959

Table 5.

Novel, low-molecular weight, pharmacological immunostimulants which may augment immunogenic cell death.

Agent Immunostimulatory Mechanism
CA-170 Targets PD-L1 and VISTA [124] *
LYC-55716 Agonist of RORγt [125]
Galunisertib Antagonist of the tyrosine kinase domain of TGF-β receptor type 1 [126]
Indoximod Prototype inhibitor of indoleamine-2,3-dioxygenase [123,127,128]
CB-1158 Granulocyte arginase inhibitor [129]
CPI-444 and AZD4635 Antagonists of the T cell A2a receptor [130,131,132]

* Denotes the relevant references as cited in the text.