Table 5.
Agent | Immunostimulatory Mechanism |
---|---|
CA-170 | Targets PD-L1 and VISTA [124] * |
LYC-55716 | Agonist of RORγt [125] |
Galunisertib | Antagonist of the tyrosine kinase domain of TGF-β receptor type 1 [126] |
Indoximod | Prototype inhibitor of indoleamine-2,3-dioxygenase [123,127,128] |
CB-1158 | Granulocyte arginase inhibitor [129] |
CPI-444 and AZD4635 | Antagonists of the T cell A2a receptor [130,131,132] |
* Denotes the relevant references as cited in the text.