Table 1.
Demographic and biochemical characteristics of the individuals classified according to the Adpn/Lep ratio.
| Adpn/Lep Ratio | ≥1.0 | ≥ 0.5 <1.0 | <0.5 | p |
|---|---|---|---|---|
| n | 51 | 50 | 191 | |
| Sex, M/F | 25/26 | 27/23 | 83/108 | 0.374 |
| Age, year | 48 ± 17 | 54 ± 16 * | 48 ± 14 † | 0.038 |
| Weight, kg | 64 ± 9 | 77 ± 16 * | 91 ± 13 *,† | <0.001 |
| BMI, kg/m2 | 21.7 ± 2.5 | 26.9 ± 5.3 * | 39.8 ± 7.9 *,† | <0.001 |
| Body adiposity, % | 25.6 ± 6.7 | 32.8 ± 6.9 * | 46.6 ± 7.6 *,† | <0.001 |
| Waist circumference, cm | 79 ± 10 | 94 ± 14 * | 117 ± 15 *,† | <0.001 |
| SBP, mm Hg | 123 ± 26 | 133 ± 21 * | 134 ± 20 * | 0.008 |
| DBP, mm Hg | 71 ± 10 | 79 ± 12 * | 82 ± 11 *,† | <0.001 |
| Glucose, mg/dL | 91 ± 16 | 99 ± 27 | 107 ± 27 *,† | <0.001 |
| Insulin, μU/mL | 4.3 ± 3.1 | 5.2 ± 3.2 | 17.3 ± 17.3 *,† | <0.001 |
| HOMA | 1.0 ± 0.7 | 1.3 ± 0.9 | 4.7 ± 4.9 *,† | <0.001 |
| QUICKI | 0.41 ± 0.05 | 0.39 ± 0.05 * | 0.33 ±0.04 *,† | <0.001 |
| Triglycerides, mg/dL | 77 ± 41 | 95 ± 62 | 140 ± 106 *,† | <0.001 |
| Total cholesterol, mg/dL | 189 ± 39 | 202 ± 42 | 204 ± 44 | 0.084 |
| LDL-cholesterol, mg/dL | 111 ± 33 | 122 ± 35 | 128 ± 36 * | 0.013 |
| HDL-cholesterol, mg/dL | 65 ± 16 | 61 ± 17 | 48 ± 12 *,† | <0.001 |
| Uric acid, mg/dL | 4.6 ± 1.1 | 5.1 ± 1.4 | 6.1 ± 1.4 *,† | <0.001 |
| CRP, mg/L | 1.4 ± 1.9 | 2.2 ± 2.8 | 7.6 ± 7.8 *,† | <0.001 |
| Fibrinogen, mg/dL | 191 ± 64 | 229 ± 93 | 349 ± 88 *,† | <0.001 |
| Homocysteine, μmol/L | 6.9 ± 2.3 | 7.8 ± 2.9 | 10.0 ± 5.4 * | 0.028 |
| WBC, 106 cells/mL | 5.4 ± 1.3 | 6.7 ± 1.9 * | 6.8 ± 1.6 * | 0.003 |
| ALT, U/L | 12 ± 7 | 16 ± 13 | 26 ± 17 *,† | <0.001 |
| AST, U/L | 14 ± 6 | 14 ± 7 | 17 ± 9 *,† | 0.016 |
| AST/ALT ratio | 1.34 ± 0.65 | 1.04 ± 0.41 * | 0.75 ± 0.38 *,† | <0.001 |
| γ-GT, U/L | 13 ± 6 | 20 ± 17 | 30 ± 28 *,† | <0.001 |
| Creatinine, mg/dL | 0.87 ± 0.15 | 0.89 ± 0.15 | 0.85 ± 0.22 | 0.326 |
| Leptin, ng/mL | 5.2 ± 2.9 | 10.4 ± 6.9 | 40.9 ± 26.6 *,† | <0.001 |
| Adiponectin, μg/mL | 12.2 ± 7.3 | 7.4 ± 4.0 * | 6.8 ± 3.5 * | <0.001 |
| Adpn/Lep ratio | 2.83 ± 2.16 | 0.74 ± 0.15 * | 0.21 ± 0.11 *,† | <0.001 |
Data presented as mean ± SD. Adpn/Lep ratio, adiponectin/leptin ratio; M, male; F, female; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HOMA, homeostatic model of assessment; QUICKI, quantitative insulin sensitivity check index; LDL, low-density lipoprotein; HDL, high-density lipoprotein; CRP, C-reactive protein; WBC, white blood cells; ALT, alanine aminotransferase; AST, aspartate aminotransferase; γ-GT, γ-glutamyltransferase. Differences between groups were analyzed by ANOVA followed by LSD tests. *p < 0.05 vs. ≥ 1.0. † p < 0.05 vs. ≥ 0.5 <1.0. Differences in gender distribution were analyzed by χ2 analysis. CRP concentrations were logarithmically transformed for statistical analysis.