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. 2019 Feb 1;10(2):104. doi: 10.3390/mi10020104

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Single-cell protein analysis by using microfluidics. (a) A fully integrated microfluidic platform enabling automated phosphoprofiling of macrophage response. Adapted by permission from Reference [115], copyright American Chemical Society 2009. (b) A clinical microchip for detecting multiple cytokines of single immune cells reveals high functional heterogeneity in phenotypically similar T cells. Adapted by permission from Reference [116], copyright Nature Publishing Group 2011.