Table 3.

Other rapid-acting antidepressant agents.

Agent	Molecular Target	Reference
Scopolamine	M1/2-antagonist, AMPAR↑, mTOR↑	[81,82]
GLYX-13	Partial agonist and modulator of NMDAR, AMPAR↑	[83,84]
MGS0039, LY3020371	mGlu2/3 antagonists, AMPAR↑	[85,86,87]
L-655,708, MRK-016	NAM of α5-GABAA-R, cortex & HC-specific	[88,89]
Cannabidiol	5-HT1A-R↑, CB1↑, vmPFC	[90,91,92,93]
Psychedelics (LSD, DOI, DMT, MDMA)	TrkB→mTOR↑+BDNF↑, 5-HT2A-R↑, PFC	[94]

We list several other important compounds, which have been shown to provide antidepressant-like effects similar to ketamine and its metabolites. M1/2 Muscarinic acetylcholine Receptor Type 1 and 2, AMPAR α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, mTOR mammalian target of rapamycin, mGlu2/3 Metabotropic glutamate receptor type 2 and 3, NAM negative allosteric modulator, α5-GABA_A-R Alpha 5 subunit of the gamma-aminobutyric acid type A receptor, HC hippocampus, NMDAR N-methyl-D-aspartate receptor, 5-HT_1A-R 5-Hydroxy tryptophan receptor type 1A, CB1 Cannabinoid receptor type 1, vmPFC ventromedial prefrontal cortex, LSD lysergic acid diethylamide, DOI (2,5)-dimethoxy-4-iodoamphetamine, DMT N,N-dimethyltryptamine, MDMA (3,4)-methylenedioxymethamphetamine, TrkB Tyrosine receptor kinase B, BDNF Brain-derived neurotrophic factor, 5-HT_2A-R 5-Hydroxy tryptophan receptor type 2A, PFC Prefrontal cortex.