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. 2019 Jan 23;11(2):252. doi: 10.3390/nu11020252

Figure 4.

Figure 4

Effect of Sophora tomentosa extract (25 mg/kg, 50 mg/kg, and 100 mg/kg, po) on (A) Tyrosine hydroxylase (TH) stain and (B) TH-positive neurons in the substantia nigra of an MPTP-induced PD mouse model. Data are expressed as mean ± SEM (n = 3). * p < 0.05, ** p < 0.01, *** p < 0.001, compared with the MPTP group. Sophora tomentosa was administered for 15 consecutive days until the behavioral tests. MPTP (20 mg/kg, ip) were given two times at four-hour intervals daily for five days until the behavioral tests. MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, PD: Parkinson’s disease, SN: substantia nigra, ST: Sophora tomentosa, TH: tyrosine hydroxylase.