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. 2019 Jan 23;11(2):252. doi: 10.3390/nu11020252

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effect of Sophora tomentosa extract (25 mg/kg, 50 mg/kg, and 100 mg/kg, po) on (A) the expression of tyrosine hydroxylase, (B) the expression of α-synuclein expression, (C) the ratio of p-GSK-3β/GSK-3β, and (D) protein was determined by immunoblot assay in an MPTP-induced PD mouse model. Data are expressed as mean ± SEM (n = 5). ** p < 0.01, *** p < 0.001, compared with the MPTP group. Sophora tomentosa was administered for 15 consecutive days until the behavioral tests. MPTP (20 mg/kg, ip) were given two times at four-hour daily intervals for five days until behavioral tests. GSK-3β: glycogen synthase kinase 3β, MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, PD: Parkinson disease, p-GSK-3β: phospho GSK-3β, ST: Sophora tomentosa, TH: tyrosine hydroxylase.