Skip to main content
. 2019 Mar;189(3):513–520. doi: 10.1016/j.ajpath.2018.11.005

Figure 2.

Figure 2

LINE-1 ORF1p expression in fallopian tubal lesions. Hematoxylin and eosin (H&E) staining indicates that, in contrast to the morphologically unremarkable p53 signature lesion, the serous tubal intraepithelial carcinoma (STIC) lesion exhibits nuclear stratification, enlargement, and prominent nucleoli. p53 Immunostaining shows diffuse positivity in both the p53 signature and STIC lesion. Ki-67 immunostaining shows a high positivity ratio in the STIC lesion (approximately 15% of the tumor cells), whereas only a single, very rare Ki-67–positive cell is seen in the p53 signature lesion. Similarly, strong LINE-1 expression is observed only in STIC lesions, in comparison to no or only focal and weak staining of LINE-1 in the p53 signature lesion (red arrows) and adjacent normal-appearing fallopian tube epithelium (black arrows). Scale bars: 100 μm (left column and right column); 250 μm (middle column). Original magnifications: ×20 (left column and right column); ×10 (middle column).