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Tight G3 translational switch using a positive-feedback derepression gene circuit. In G2, the UaaRS and tRNACUA are expressed even in the OFF-state, causing a significant level of leakage translation. A positive-feedback derepression circuit from the Uaa-tRNACUA to the UaaRS and/or tRNACUA gene decreases the expression level of those genes in the OFF-state, resulting in a suppression of leakage translation.
