Table II.
KEGG functional annotation of the Bepridil targets.
| Gene set | Description | Count | P-value | Gene |
|---|---|---|---|---|
| hsa00480 | Glutathione metabolism | 7 | 0.0022 | GPX1; GPX4; ANPEP; GSTA1; GSTA4; GSTP1; ODC1 |
| hsa04964 | Proximal tubule bicarbonate reclamation | 5 | 0.0029 | ATP1A1; PCK1; PCK2; CA2; SLC4A4 |
| hsa04514 | Cell adhesion molecules | 13 | 0.0040 | VCAN; CADM1; HLADQB1; ITGA4; ITGAV; CD99; NCAM1; CLDN18; PTPRM; SDC2; SDC4; CD58; CDH1 |
| hsa05206 | microRNAs in cancer | 14 | 0.0058 | SPRY2; CDKN1B; CRK; E2F2; DICER1; TNC; MARCKS; ABCB1; SERPINB5; PIK3R2; PRKCB; SOX4; THBS1; CCND2 |
| hsa04924 | Renin secretion | 8 | 0.0069 | ADCYAP1R1; CLCA1; AGT; PDE1A; PDE1C; PDE1B; PTGER4; CLCA2 |
| hsa04972 | Pancreatic secretion | 10 | 0.0077 | CLCA1; SLC26A3; KCNQ1; ATP1A1; PLA2G2A; PRKCB; SLC12A2; CA2; SLC4A4; CLCA2 |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 9 | 0.0136 | FGFR2; GAS6; NRG1; IGF1R; PIK3R2; PRKCB; AXL; PDGFC; BCL2L1 |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | 12 | 0.0161 | FZD10; FGFR2; FGFR4; ID3; ID4; IGF1R; INHBB; SMAD3; PIK3R2; WNT5A; NANOG; KLF4 |
| hsa04614 | Renin-angiotensin system | 4 | 0.0176 | CTSG; AGT; ANPEP; CTSA |
| hsa00010 | Glycolysis/gluconeogenesis | 7 | 0.0225 | ALDH2; ALDOB; HK2; PCK1; PCK2; PFKP; PGK1 |
| hsa04512 | ECM-receptor interaction | 8 | 0.0259 | COL6A3; TNC; ITGA4; ITGAV; LAMB1; SDC4; THBS1; CD47 |
| hsa01230 | Biosynthesis of amino acids | 7 | 0.0289 | ALDOB; IDH3G; PFKP; PGK1; PSPH; BCAT1; PYCRL |
| hsa00330 | Arginine and proline metabolism | 5 | 0.0332 | ALDH2; OAT; ODC1; SMOX; PYCRL |
| hsa05032 | Morphine addiction | 8 | 0.0343 | GABRP; PDE1A; PDE1C; PDE2A; PDE1B; PRKCB; GNG12; CACNA1A |
| hsa00910 | Nitrogen metabolism | 3 | 0.0409 | CA1; CA2; CA12 |
| hsa05215 | Prostate cancer | 8 | 0.0531 | CDKN1B; E2F2; FGFR2; GSTP1; HSP90AA1; IGF1R; PIK3R2; PDGFC |
| hsa04974 | Protein digestion and absorption | 7 | 0.0585 | COL5A2; COL6A3; COL10A1; COL13A1; KCNQ1; ATP1A1; SLC1A1 |
| hsa04310 | Wnt signaling pathway | 10 | 0.0609 | FZD10; DKK1; SMAD3; PRKCB; SFRP1; SFRP4; TBL1X; WNT5A; TBL1XR1; CCND2 |
| hsa04510 | Focal adhesion | 14 | 0.0629 | COL6A3; CRK; TNC; IGF1R; ITGA4; ITGAV; LAMB1; MYLK; PIK3R2; PRKCB; PDGFC; ACTB; THBS1; CCND2 |
| hsa04068 | FoxO signaling pathway | 10 | 0.0730 | CDKN1B; PRMT1; IGF1R; SMAD3; FOXO4; PCK1; PCK2; PIK3R2; S1PR4; CCND2 |
| hsa04350 | TGF-β signaling pathway | 7 | 0.0742 | ID3; ID4; INHBB; SMAD3; BMP6; TFDP1; THBS1 |
| hsa05205 | Proteoglycans in cancer | 14 | 0.0751 | FZD10; ANK1; IGF1R; ITGAV; PIK3R2; PRKCB; PTCH1; ACTB; SDC2; SDC4; THBS1; TWIST1; WNT5A; NANOG |
| hsa05020 | Prion diseases | 4 | 0.0764 | HSPA1A; NCAM1; PRNP; C7 |
| hsa05130 | Pathogenic Escherichia coli infection | 5 | 0.0849 | ARPC1A; KRT18; ACTB; TUBB6; CDH1 |
| hsa05222 | Small cell lung cancer | 7 | 0.0874 | CDKN1B; CKS2; E2F2; ITGAV; LAMB1; PIK3R2; BCL2L1 |
| hsa04971 | Gastric acid secretion | 6 | 0.0877 | KCNQ1; MYLK; ATP1A1; PRKCB; ACTB; CA2 |
| hsa05202 | Transcriptional misregulation in cancer | 12 | 0.0906 | CDKN1B; ELANE; FUT8; NUPR1; HPGD; IGF1R; LMO2; MMP3; MPO; BCL2A1; BCL2L1; CCND2 |
| hsa04151 | PI3K-Akt signaling pathway | 20 | 0.0920 | CDKN1B; COL6A3; FGFR2; FGFR4; HSP90AA1; TNC; IGF1R; IL2RG; ITGA4; ITGAV; LAMB1; PCK1; PCK2; PIK3R2; GNG12; PDGFC; BCL2L1; THBS1; YWHAB; CCND2 |
| hsa03320 | PPAR signaling pathway | 6 | 0.0930 | PLIN2; FABP1; FABP5; ACSL1; PCK1; PCK2 |
| hsa04110 | Cell cycle | 9 | 0.0986 | CDKN1B; CDKN1C; E2F2; SMAD3; MCM4; TFDP1; YWHAB; CCND2; CDC20 |
KEGG, Kyoto Encyclopedia of Genes, and Genomes; EGFR, epidermal growth factor receptor; ECM, extracellular matrix; Fox, forkhead box; TGF, transforming growth factor; PI3K-Akt, phosphatidylinositol 3 kinase-protein kinase B; PPAR, peroxisome proliferator-activated receptor.