Table 4.
Glucose | Insulin | TAG | TAC | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Hibiscus | Water | p Value | Hibiscus | Water | p Value | Hibiscus | Water | p Value | Hibiscus | Water | p Value | |
AUC 0–240 min | 1384 ± 47 | 1455 ± 56 | 0.058 | 49,242 ± 8666 | 50,017 ± 7661 | 0.424 | 547± 55 | 605 ± 71 | 0.188 | 343 ± 50 | 318 ± 40 | 0.105 |
IAUC 0–240 min | 80 ± 40 | 134 ± 51 | 0.090 | 35,962 ± 6588 | 37,561 ± 6554 | 0.465 | 157 ± 28 | 196 ± 26 | 0.128 | 79.0 ± 38 | 75.8 ± 25 | 0.478 |
Tmax 0–240 min | 139 ± 14.5 | 135 ± 15 | 0.408 | 126 ± 13 | 123 ± 14 | 0.500 | 196 ± 6 | 196 ± 6 | 0.380 | 153 ± 14 | 175 ± 10 | 0.100 |
Cmax 0–240 min | 7.5 ± 0.3 | 7.6 ± 0.3 | 0.052 | 387 ± 61 | 403 ± 49 | 0.482 | 3.3 ± 0.3 | 3.6 ± 0.4 | 0.246 | 2.2 ± 0.3 | 2.3 ± 0.4 | 0.460 |
AUC 0–120 min | 706 ± 23 | 722 ± 30 | 0.143 | 23,629 ± 3932 | 23,388 ± 3551 | 0.303 | 222 ± 23 | 324 ± 34 | 0.143 | 150 ± 17 * | 130 ± 11 | 0.026 |
IAUC 0–120 min | 53.8 ± 19.3 | 61.8 ± 24.6 | 0.209 | 16,988 ± 2935 | 17,160 ± 3100 | 0.383 | 27.5 ± 6.8 | 46.1 ± 19.5 | 0.209 | 18.4 ± 10.9 | 9.4 ± 5.3 | 0.209 |
Tmax0–120 min | 68.4 ± 5.3 | 53.2 ± 5.2 | 0.059 | 64.4 ± 4.3 | 65.5 ± 5.1 | 0.191 | 110 ± 5 | 196 ± 6 | 0.060 | 96.3 ± 7.4 * | 75.0 ± 8.1 | 0.007 |
Cmax0–120 min | 6.9 ± 0.3 | 7.1 ± 0.3 | 0.201 | 339 ± 60 | 338 ± 49 | 0.344 | 2.4 ± 0.2 | 3.3 ± 0.3 | 0.201 | 1.7 ± 0.3 | 1.4 ± 0.1 | 0.056 |
AUC 121–240 min | 678 ± 37 | 733± 31 | 0.065 | 25,614 ± 4838 | 26,629 ± 4288 | 0.472 | 239 ± 29 | 365 ± 43 | 0.065 | 192 ± 33 | 187 ± 30 | 0.340 |
IAUC 121–240 min | 95 ± 36 | 109 ± 33 | 0.272 | 10,457 ± 2477 | 10,782 ± 2141 | 0.449 | 34.7 ± 7.9 | 76.3 ± 16.2 | 0.272 | 21.5 ± 16.7 | 50.9 ± 15.6 | 0.067 |
Tmax121–240 min | 189 ± 7 | 188± 6 | 0.398 | 185 ± 5 | 177 ± 4 | 0.072 | 108 ± 6 | 196 ± 6 | 0.398 | 176 ± 8 | 187 ± 8 | 0.140 |
Cmax121–240 min | 7.2 ± 0.3 * | 7.5 ± 0.3 | 0.040 | 365 ± 61 | 347 ± 46 | 0.218 | 2.5 ± 0.3 | 3.6 ± 0.4 | 0.040 | 2.1 ± 0.4 | 2.2 ± 0.4 | 0.440 |
Values are mean ± SEM of 22 volunteers. Superscript * means significant difference when compared to water. Area under curve (AUC); incremental area under curve (IAUC); time to reach total maximum concentration (Tmax); maximum concentration (Cmax); triacylglycerol (TAG); total antioxidant capacity (TAC). AUC, IAUC, AUC and IAUC for glucose, insulin, TAG and TAC are expressed as mmol/L·minutes, pmol/L·minutes, mmol/L·minutes and mmol/L. Trolox Eq·minutes respectively. Tmax is in minutes, Cmax is in mmol/L for glucose and TAG; mmol/L Trolox Eq for TAC and as pmol/L for insulin.