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. 2019 Feb 9;11(2):363. doi: 10.3390/nu11020363

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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12-Lipoxygenase-derived monohydroxy lipid mediators directly before and after apheresis therapy. (A) Arachidonic acid (AA, 20:4 n-6)-derived 12-hydroxyeicosatetraenoic acid (12-HETE); (B) Eicosapentaenoic acid (EPA, 20:5 n-3)-derived 12-hydroxyeicosapentaenoic acid (12-HEPE); and (C) Docosahexaenoic acid (DHA, 22:6 n-3)-derived 14-hydroxydocosahexaenoic acid (14-HDHA). Differences within one treatment group pre- to post-apheresis were not significant for either HELP, MDF, or DA. Analysis was performed by two-tailed paired Student’s t-test. Differences between the treatment groups did not reach statistical significance as analyzed with one-way ANOVA.