Figure 4.

15-Lipoxygenase-derived monohydroxy lipid mediators directly before and after apheresis therapy. (A) Linoleic acid (LA, 18:2 n-6)-derived 13-hydroxyoctadecadienoic acid (13-HODE); (B) AA-derived 15-hydroxyeicosatetraenoic acid (15-HETE); (C) EPA-derived 15-hydroxyeicosapentaenoic acid (15-HEPE); and (D) DHA-derived 17-hydroxydocosahexaenoic acid (17-HDHA). Differences within one treatment group between pre- and post-lipoprotein apheresis were significant where indicated (* p < 0.05, ** p < 0.01). Analysis was performed by two-tailed paired Student’s t-test.