Figure 5.

Cytochrome P450 (CYP450)-derived epoxy lipid mediators measured before and after apheresis therapy. (A) LA-derived 9,10-epoxyoctadecenoic acid (9,10-EODE); (B) AA-derived 14,15-epoxyeicosatrienoic acid (14,15-EET); (C) EPA-derived 14,15-epoxyeicosatetraentaenoic acid (14,15-EEQ); and (D) DHA-derived 19,20-epoxydocosapentaenoic acid (19,20-EDP). Differences pre- and post-lipoprotein apheresis within one treatment group were significant when indicated (* p < 0.05, ** p < 0.01). Analysis was performed by two-tailed paired Student’s t-test.