Table 2.

Concentrations and standard deviations of plasma polyunsaturated fatty acids in patients undergoing HELP, MDF, or DA apheresis. (n = 17 for HELP, n = 9 for MDF, and n = 7 for direct adsorption (DA)). Differences between the groups were only significant when indicated (* p < 0.05, ** p < 0.01, *** p < 0.001). Analysis was performed by two-tailed paired Student’s t-test.

FA Group	HELP			MDF			DA
	pre	post		pre	post		pre	post
	conc. mg/mL	conc. mg/mL	% change	conc. mg/mL	conc. mg/mL	% change	conc. mg/mL	conc. mg/mL	% change
n-3 FA
C18:3 n-3	26.04 ± 13.43	16.74 ** ± 7.13	−35.71	23.03 ± 12.28	14.53 ± 5.11	−36.9	41.01 ± 29.30	24.57 ± 15.96	−40.1
C20:5 n-3	39.99 ± 16.96	28.79 ** ± 16.80	−28.01	57.21 ± 35.47	48.98 ± 30.00	−14.4	66.12 ± 41.47	37.87 * ± 23.15	42.7
C22:5 n-3	18.54 ± 7.22	13.09 *** ± 5.12	−29.38	17.27 ± 7.18	15.59 ± 6.63	−9.8	23.94 ± 8.34	14.98 ± 4.04	−37.4
C22:6 n-3	61.26 ± 15.25	45.93 *** ± 18.20	−25.02	60.49 ± 27.80	56.93 ± 27.76	−5.9	92.14 ± 41.66	60.86 ** ± 26.71	−33.9
n-6 FA
C18:2 n-6	713.11 ± 209.94	488.11 *** ± 150.23	−31.55	515.50 ± 195.36	430.18 ± 183.21	−16.6	903.77 ± 338.23	508.98 ** ± 189.83	−43.7
C18:3 n-6	12.29 ± 7.17	7.25 *** ± 4.22	−41.01	7.84 ± 4.23	7.03 ± 4.66	−10.4	15.76 ± 7.64	8.15 ** ± 4.32	−48.3
C20:2 n-6	6.18 ± 2.62	4.53 ** ± 2.50	−26.74	4.20 ± 1.40	3.87 ± 2.30	−8.0	7.17 ± 2.54	4.70 ** ± 1.67	−34.4
C20:3 n-6	40.57 ± 10.76	30.03 *** ± 9.75	−25.98	28.35 ± 9.57	29.69 ± 17.12	−4.7	52.93 ± 23.88	33.56 *** ± 16.64	−36.6
C20:4 n-6	205.57 ± 78.59	151.68 *** ± 64.79	−26.22	143.67 ± 42.91	154.43 ± 91.39	−7.5	259.19 ± 51.58	158.45 *** ± 33.10	−38.9
C22:4 n-6	5.31 ± 3.02	3.52 *** ± 2.23	−33.66	2.98 ± 1.28	3.21 ± 2.03	−7.7	5.77 ± 1.75	3.69 ** ± 1.17	−36.7
MU-FA
C14:1 n-5	2.83 ± 2.39	1.54 * ± 1.35	−45.63	2.79 ± 1.68	1.90 ± 1.19	−31.88	3.04 ± 2.39	1.68 ** ± 1.87	−44.65
C16:1 n-7	76.31 ± 66.30	48.31 ** ± 45.88	−36.69	54.16 ± 27.30	51.94 ± 38.10	−4.09	98.97 ± 70.18	55.16 * ± 40.86	−44.26
C18:1 n-9c	822.93 ± 436.22	545.52 ** ± 326.87	−33.71	546.09 ± 192.72	481.01 ± 288.90	−11.92	1077.42 ± 512.09	665.84 * ± 311.13	−38.2
C18:1 n-7c	71.11 ± 35.72	47.87 *** ± 28.26	−32.86	48.86 ± 15.11	47.01 ± 27.14	−3.78	90.70 ± 38.51	90.70 ** ± 38.51	−38.29
C20:1 n-9	7.63 ± 4.40	5.73 * ± 3.70	−24.94	4.33 ± 1.53	3.89 ± 2.36	−10.04	10.07 ± 4.87	6.74 * ± 3.17	−33.03
C22:1 n-9	1.54 ± 1.36	1.65 ± 1.35	6.87	1.44 ± 0.41	1.10 ± 0.70	−23.38	2.38 ± 1.78	2.25 ± 1.48	−5.56
C24:1 n-9	27.66 ± 6.11	18.61 *** ± 5.99	−32.71	20.99 ± 5.89	20.28 ± 10.83	−3.41	40.38 ± 10.59	20.60 *** ± 7.23	−48.98
S-FA
C12:0	5.78 ± 5.24	5.49 ± 6.78	−5.05	5.01 ± 3.66	3.93 ± 3.04	−21.51	6.46 ± 2.03	3.23 ** ± 2.95	−50.03
C14:0	43.39 ± 32.30	25.70 * ± 19.34	−40.76	38.11 ± 19.63	27.90 ± 17.41	−26.80	49.70 ± 30.96	27.72 * ± 24.01	−44.22
C16:0	631.74 ± 183.78	446.20 * ± 152.09	−29.37	594.37 ± 223.44	448.72 ± 186.17	−24.51	782.43 ± 115.50	532.66 * ± 92.20	−31.92
C17:0	9.44 ± 3.73	6.27 *** ± 2.42	33.60	7.18 ± 2.69	6.27 ± 2.74	−12.63	10.26 ± 3.64	6.38 ** ± 2.25	37.81
C18:0	245.11 ± 89.13	180.60 *** ± 79.90	−33.71	175.23 ± 64.06	164.04 ± 84.84	−6.39	285.69 ± 88.19	192.91 ** ± 57.01	−32.48
C20:0	6.44 ± 2.13	4.48 *** ± 2.01	−30.40	4.73 ± 1.67	4.35 ± 2.07	−8.01	8.86 ± 3.05	4.97 ** ± 1.43	−43.89
C22:0	15.44 ± 5.14	10.38 *** ± 4.55	−32.76	11.43 ± 4.19	9.69 ± 4.95	−15.21	23.56 ± 5.92	12.37 *** ± 5.34	−47.51
C24:0	11.13 ± 3.75	7.29 *** ± 2.76	−34.49	8.41 ± 3.45	7.66 ± 3.62	−8.94	16.34 ± 3.81	7.89 *** ± 2.39	−51.7