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. 2019 Feb 13;20(4):794. doi: 10.3390/ijms20040794

Table 1.

Association of subjective or objective sleep duration and quality with carotid IMT and baPWV in patients with atherosclerotic risk factors.

Surrogate Marker of Atherosclerosis Sleep Parameter Study Design Subjects Sleep Measurement Comments References
Carotid intima media thickness (IMT) Duration Cross-sectional Elderly (n = 86) PSQI
Actigraphy
Shorter sleep duration (<5 h) increased IMT as compared to longer duration (>7 h) Nakazaki et al. [19]
Quality Cross-sectional Elderly (n = 86)
Elderly (n = 201)
Type 2 diabetes mellitus (n = 63)
Cardiovascular risk factors (n = 330)
Self-reported questionnaire
Single-channel EEG
Actigraphy
Insomnia associated with IMT as compared with non-insomnia Nakazaki et al. [19]
Nagai et al. [20]
Yoda et al. [21]
Kadoya et al. [11]
Apnea-hypopnea Cross-sectional Cardiovascular risk factors (n = 330) Apnomonitor OSA associated with IMT and plaque score Kadoya et al. [11]
Brachial-ankle pulse wave velocity (baPWV) Quality Cross-sectional Type 2 diabetes mellitus (n = 724) PSQI Poor sleep quality associated with higher PWV Osonoi et al. [22]
Prospective Cardiovascular risk factors (n = 306) Actigraphy Low sleep quality associated with progression of PWV over 3-year period Kadoya et al. [18]
Apnea-hypopnea Cross-sectional Ischemic stroke (n = 127) Polysomnography OSA associated with PWV Chen et al. [10]

PSQI: Pittsburg sleep quality index, EEG: electro-encephalography: OSA: obstructive sleep apnea.