Table 1.
Study characteristics regarding thyroid auto-antibodies.
| Studies | Type of Study | Type of Auto-Antibodies | Study Group | Control Group | Clinical Pregnancy Rate | Live Birth/Ongoing Pregnancy Rate | Miscarriage Rate | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Study Group | Control Group | Study Group | Control Group | Study Group | Control Group | |||||
| Chen et al., 2017 a [11] | Prospective | TPO-Ab, TG-Ab | 235 TG-AB (+), 214 TPO-Ab (+) | 844 TAA (−) women | 59.6%, 54.2% | 61% | 54.4%, 51.4% | 55.90% | 5.1%, 2.8% | 5.10% |
| Caccavo et al., 2016 [23] | Prospective | TPO-Ab, TG-Ab, Anti-laminin 1 | 44 Infertile Women affected by HT | 28 Infertile Women without HT | 9.1% | 31.1% | n/a | n/a | n/a | n/a |
| Sakar et al., 2016 [32] | Prospective | TPO-Ab, TG-Ab | 31 (32 cycles) TAA (+) women | 121 (126 cycles) TAA (−) women | 21.90% | 20.60% | 15.60% | 15.10% | 6.30% | 5.50% |
| Lukaszuk et al., 2015 [27] | Retrospective | TPO-Ab | 114 TAA (+) women | 495 TAA (−) women | 43.80% | 47.50% | 30.40% | 34.10% | 13.10% | 13.30% |
| Tan et al., 2014 [33] | Retrospective | TPO-Ab, TG-Ab | 110 TAA (+) women | 725 TAA (−) women | 40.9% | 41.51% | 39.09% | 37.38% | 4.44% | 9.96% |
| Mintzori et al., 2014 [34] | Retrospective | TPO-Ab, TG-Ab | 15 TAA (+) women | 67 TAA (−) women | 33.33% | 37.31% | 26.67% | 34.32% | 20% | 8% |
| Chai et al., 2014 [24] | Retrospective | TPO-Ab, TG-Ab | 89 TAA (+) women | 419 TAA (−) women | 44.90% | 45.80% | 32.60% | 36% | 9% | 8.80% |
| Karacan et al., 2013 [25] | Prospective | TPO-Ab, TG-Ab | 34 TAA (+) women | 219 TAA (−) women | 35.30% | 40.60% | 32.40% | 37% | 2.90% | 3.60% |
| Magri et al., 2013 [28] | Retrospective | TPO-Ab, TG-Ab | 60 TAA (+) women | 202 TAA (−) women | 28% | 35% | n/a | n/a | n/a | n/a |
| Zhong et al., 2012 [9] | Retrospective | TPO-Ab, TG-Ab | 90 TAA (+) women | 676 TAA (−) women | 33.3% | 46.7% | 24.33% | 41.20% | 8.97% | 5.50% |
| Monteleone et al., 2011 [29] | Prospective | TPO-Ab, TG-Ab | 14 TAA (+) women | 17 TAA (−) women | n/a | n/a | n/a | n/a | 40% | 17% |
| Revelli et al., 2009 [31] | Retrospective | TPO-Ab, TG-Ab | 52 TAA (+) women | 200 TAA (−) women | 7.6% | 33% | 6% | 29% | 25% | 12% |
| Kilic et al., 2008 [26] | Cross-sectional and Prospective | TPO-Ab, TG-Ab | 23 TAA (+) women | 31 TAA (−) women | 30.40% | 41.90% | n/a | n/a | n/a | n/a |
| Negro et al., 2007 [30] | Retrospective | TPO-Ab | 42 TAA (+) women | 374 TAA (−) women | 50% | 62.60% | 28.57% | 55.34% | 11.90% | 7.20% |
a: Chen et al., 2017, presents patients positive for more than one auto-antibody, thus cumulative results cannot be provided.