Table 4.

Study characteristics regarding auto-antibodies affecting the reproductive system.

Studies	Type of Study	Type of Auto-Antibodies	Study Group	Control Group	Clinical Pregnancy Rate		Live Birth/Ongoing Pregnancy Rate		Miscarriage Rate
					Study Group	Control Group	Study Group	Control Group	Study Group	Control Group
Rogenhofer et al., 2015 [82]	Case Report	−AGA	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Subit et al., 2011 [83]	Prospective	−AEA	−AEA+ 296 Single IUI cycles 105 double IUI cycles	AEA− 673 single IUI cycles 169 double IUI cycles	4.01% 14.29%	13.07% 16.57%	n/a	n/a	n/a	n/a
Zini et al., 2011 [91]	Prospective	−ASA	−26 ASA(+) Men	−225 ASA(−) Men	42%	52%	n/a	n/a	n/a	n/a
Caccavo et al., 2011 [85]	Prospective	aLN-1	−11 aLN-1 positive women with endometriosis	24 aLN-1 negative women with endometriosis	n/a	n/a	36%	29%	n/a	n/a
Sarapik et al., 2010 [86]	Not provided	−AEA	−190 AEA positive women	n/a	OR: IgA: 0.95 IgG: 1.00 a	n/a	n/a	n/a	n/a	n/a
Francavilla et al., 2009 [87]	Cross-Over	−ASA	−38 ASA positive men	−212 ASA negative OAT men	19% (without COH) 17.6% (with COH)	2.9% (without COH) 6.4% (with COH	n/a	n/a	n/a	n/a
Randall et al., 2009 [88]	Not provided	AEA	Not Provided b
Van Weert et al., 2008 [89]	Prospective	ASA	−43 ASA positive men	−430 ASA negative men	20.93%	25.76%	n/a	n/a	n/a	n/a
Esteves et al., 2007 [90]	Retrospective	−ASA	17 men with 50% or more ASA	301 men with 20% or less ASA	47.06%	53.16%	n/a	n/a	25%	17.94%

^a: The study provided only odds ratio for IgA and IgG, as well as certain molecular weight IgAs and IgGs; ^b:The raw data of the study could not be obtained. A total of 352 patients were included and miscarriage was higher in the AEA positive group.