Table 2.
Striatal sub-region estimates, correlations, and significance values for OFF and ON medication for PD patients and controls.
| Volume | PD (n = 24) |
Control (n = 18) |
||||||
|---|---|---|---|---|---|---|---|---|
| OFF | ON | r | p | OFF | ON | r | p | |
| Total | 19,296.4 (469.3) | 18,974.1 (410.9) | 0.819 | *** | 18,412.0 (480.1) | 18,418.7 (465.8) | 0.985 | *** |
| Accumbens | 2335.2 (99.9) | 2347.2 (50.5) | 0.652 | ** | 2237.9 (73.4) | 2217.6 (67.9) | 0.944 | *** |
| Putamen | 9346.8 (305.1) | 9217.6 (212.7) | 0.688 | *** | 8840.0 (181.1) | 8891.7 (192.5) | 0.981 | *** |
| Caudate | 7124.0 (254.5) | 7146.8 (238.7) | 0.521 | * | 7007.5 (264.5) | 7002 (254.4) | 0.984 | *** |
| Caudal-motor | 1546.2 (88.4) | 1628.9 (99.4) | 0.621 | ** | 1866.5 (110.5) | 1772.8 (121.2) | 0.575 | * |
| Rostral-motor | 1081.7 (118.1) | 986.0 (108.5) | 0.835 | *** | 1008.3 (120.7) | 1139.7 (150.6) | 0.929 | *** |
| Executive | 15,311.1 (551.8) | 14,836.8 (455.5) | 0.847 | *** | 13,976.2 (784.0) | 14,109.6 (776.0) | 0.961 | *** |
| Limbic | 1570.4 (151.9) | 1659.7 (140.5) | 0.610 | ** | 1504.4 (259.8) | 1416.8 (239.4) | 0.948 | *** |
| Parietal | 2041.6 (160.7) | 2023.5 (121.8) | 0.601 | ** | 2294.4 (126.9) | 2223.0 (119.7) | 0.662 | ** |
| Occipital | 615.7 (54.3) | 532.6 (60.1) | 0.700 | *** | 589.1 (78.5) | 593.3 (76.9) | 0.893 | *** |
| Temporal | 604.9 (128.1) | 575.3 (93.1) | 0.452 | * | 664.5 (148.0) | 700.5 (114.4) | 0.598 | ** |
| Displacement | PD | Control | ||||||
| OFF | ON | r | p | OFF | ON | r | p | |
| Caudal-motor | −0.654 (0.178) | −0.679 (0.179) | 0.985 | *** | −0.296 (0.74) | −0.324 (0.069) | 0.727 | *** |
| Rostral-motor | −0.691 (0.124) | −0.660 (0.122) | 0.831 | *** | −0.399 (0.088) | −0.427 (0.085) | 0.800 | *** |
| Executive | −0.077 (0.058) | −0.089 (0.057) | 0.964 | *** | 0.0488 (0.032) | 0.037 (0.037) | 0.948 | *** |
| Limbic | 0.758 (0.114) | 0.816 (0.117) | 0.891 | *** | 0.746 (0.142) | 0.759 (0.144) | 0.893 | *** |
| Parietal | −0.035 (0.058) | −0.060 (0.069) | 0.922 | *** | 0.009 (0.036) | −0.001 (0.030) | 0.767 | *** |
| Occipital | 0.416 (0.071) | 0.401 (0.066) | 0.812 | *** | 0.374 (0.069) | 0.357 (0.068) | 0.891 | *** |
| Temporal | 0.193 (0.131) | 0.146 (0.136) | 0.936 | *** | 0.322 (0.109) | 0.307 (0.114) | 0.980 | *** |
| Fractional Anisotropy | PD | Control | ||||||
| OFF | ON | r | p | OFF | ON | r | p | |
| Caudal-motor | 0.327 (0.009) | 0.326 (0.008) | 0.840 | *** | 0.348 (0.008) | 0.352 (0.009) | 0.863 | *** |
| Rostral-motor | 0.426 (0.006) | 0.430 (0.006) | 0.741 | *** | 0.420 (0.007) | 0.423 (0.007) | 0.921 | *** |
| Executive | 0.332 (0.004) | 0.323 (0.005) | 0.881 | *** | 0.339 (0.004) | 0.340 (0.005) | 0.827 | *** |
| Limbic | 0.335 (0.007) | 0.327 (0.007) | 0.645 | ** | 0.339 (0.007) | 0.341 (0.008) | 0.900 | *** |
| Parietal | 0.391 (0.004) | 0.393 (0.004) | 0.653 | ** | 0.390 (0.008) | 0.385 (0.010) | 0.924 | *** |
| Occipital | 0.437 (0.005) | 0.440 (0.004) | 0.697 | *** | 0.434 (0.009) | 0.433 (0.009) | 0.983 | *** |
| Temporal | 0.344 (0.005) | 0.345 (0.004) | 0.470 | * | 0.360 (0.005) | 0.361 (0.005) | 0.867 | *** |
Values are reported as mean (SEM). Volume, displacement and fractional anisotropy (FA) estimates are presented for both PD patients and controls, off and on medication. Pearson correlation coefficients (r) between on and off sessions are presented, along with the corresponding significance (p) value, corrected for multiple comparisons using Bonferroni correction. ***p < 0.001, **p < 0.01, *p < 0.05.