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. 2019 Feb 14;24(4):673. doi: 10.3390/molecules24040673

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The role of checkpoint kinase 2 (Chk2) in theaflavin-3, 3′-digallate (TF3)-induced apoptosis. (A,B) Blocking Chk2 impaired TF3-induced apoptosis. (C) Blocking Chk2 partially reversed TF3-induced increase of the expression of p-Chk2, Bax and cleaved poly (ADP-ribose) polymerase 1 (PARP-1), as well as a decrease of the expression of Bcl-xL. (C1–C7) Densitometry analysis of protein bands. (D–F) Blocking Chk2 attenuated the activation of Caspase-3/7 and 9 induced by TF3. However, the activity of Caspase-8 was not affected. * p < 0.05 compared with control or between specific groups.