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. 2019 Feb 19;20(4):903. doi: 10.3390/ijms20040903

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Case 1: sacral pressure ulcer progression through healing after activated protein C (APC) administration. On day 0, the wound had a central depth of 10 mm. At day 7, the wound was 20 mm in diameter. Rapid growth of granulation tissue is apparent from day 7 to day 16. At day 16, the diameter was 18 mm. On day 21, the diameter was 14 mm, and by day 24 the wound was 6 mm in diameter. Therapy was stopped at this point. At day 28, the diameter was 5 mm. Final follow-up at day 35 showed that the wound had healed completely. No images of the follow-up. © 2014 The Authors. International Wound Journal © 2014 Medicalhelplines.com Inc and John Wiley & Sons Ltd. Reproduced with permission. License number 4525880595450.