Table 4.
Notable examples of mutational studies for cytoprotection.
| Study | Name | Mutation | Effects |
|---|---|---|---|
| Mosnier et al. [95] | 229/230-APC | Alanine mutations of FVa-binding residues (RR229/230AA) | Reduced anticoagulant activity, with normal anti-apoptotic functions |
| Mosnier et al. [95] | 3K3A-APC | Alanine mutations of FVa-binding residues (KKK191_ 193AAA) | |
| Mosnier et al. [97] | 5A-APC | RR229/230AA and KKK191_ 193AAA | |
| Bae et al. [98] | No name given | Disulfide bond between two β-sheets (Cys67-Cys82) | |
| Ni Ainle et al. [115] | APC-L38D/N329Q | Elimination of an N-linked glycan attachment site (L38D/N329Q) | Reduced anticoagulant activity, and improved endothelial barrier protective and anti-apoptotic functions |