Table 2.

Regression coefficients (β) of association of pregnancy (time), dietary intake and supplemental intake with changes in folate, vitamin B6, vitamin B12, 25(OH)D and ferritin blood levels.

Outcome	Characteristic	β	95% CI	p-Value
Folate status b (nmol/l)	Time—12 weeks pregnancy a	3.14	−1.33; 7.62	0.166
	Time—24 weeks pregnancy a	0.20	−3.69; 4.10	0.917
	Supplemental folate intake (FE μg)	0.026	0.020; 0.031	<0.001
	Dietary folate intake (FE μg)	−0.015	−0.044; 0.014	0.297
Vitamin B6 status c (nmol/L)	Time—12 weeks pregnancy a	−1.70	−9.10; 5.70	0.647
	Time—24 weeks pregnancy a	−10.3	−17.5; −3.25	0.005
	Supplemental vitamin B6 intake (mg)	2.15	0.89; 3.43	0.001
	Dietary vitamin B6 intake (mg)	1.17	−9.42; 11.8	0.826
Vitamin B12 status d (pmol/L)	Time—12 weeks pregnancy a	−55.2	−74.0; −36.4	<0.001
	Time—24 weeks pregnancy a	−91.1	−109; −73.1	<0.001
	Supplemental vitamin B12 intake (μg)	0.52	−0.55; 1.59	0.336
	Dietary vitamin B12 intake (μg)	5.06	−1.76; 11.9	0.143
25(OH)D status e (nmol/L)	Time—12 weeks pregnancy a	17.0	9.90; 24.0	<0.001
	Time—24 weeks pregnancy a	33.5	25.7; 41.3	<0.001
	Supplemental vitamin D intake (μg)	1.03	0.51; 1.54	<0.001
	Dietary vitamin D intake (μg)	6.66	3.78; 9.55	<0.001
Ferritin status f (µg/L)	Time—12 weeks pregnancy a	−5.75	−12.4; 0.88	0.088
	Time—24 weeks pregnancy a	−23.0	−28.2; −17.8	<0.001
	Supplemental iron intake (mg)	0.12	−0.12; 0.36	0.328
	Dietary iron intake (mg)	−0.22	−1.45; 1.01	0.723

^a Preconception is reference category. ^b Estimates are adjusted for age, education level, season of blood collection, BMI, energy intake, vitamin B12 and B6 intake. ^c Estimates are adjusted for age, educational level, vitamin B12 intake and energy intake. ^d Estimates are adjusted for parity, season of blood collection, BMI, energy intake, vitamin B6 intake. ^e Estimates are adjusted for education level, parity, season of blood collection, BMI and energy intake. ^f Estimates are adjusted for alcohol intake, nausea during pregnancy, BMI and energy intake.