Table 2.
Changes in SBP/DBP and HR after ingestion of tomato pomace extracts across 3 different doses (Phase 1 study: tolerance).
| Dose/Variable | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| 0 h | 3 h | 0 h | 3 h | 0 h | 3 h | 0 h | 3 h | 0 h | 3 h | |
| TP extract = 1.0 g | ||||||||||
| SBP | 120 ± 8 | 120 ± 11 | 113 ± 11 | 113 ± 7 | 116 ± 6 | 112 ± 11 | 117 ± 12 | 110 ± 7 | 108 ± 8 | 119 ± 10 |
| DBP | 74 ± 14 | 70 ± 8 | 70 ± 8 | 68 ± 10 | 71 ± 8 | 72 ± 4 | 67 ± 8 | 64 ± 4 | 64 ± 7 | 68 ± 11 |
| HR | 65 ± 5 | 69 ± 4 | 62 ± 4 | 72 ± 9 | 69 ± 11 | 74 ± 13 | 64 ± 8 | 72 ± 8 | 63 ± 5 | 69 ± 6 |
| TP extract = 2.5 g | ||||||||||
| SBP | 110 ± 12 | 104 ± 10 | 116 ± 4 | 109 ± 8 | 118 ± 11 | 109 ± 8 | 116 ± 7 | 108 ± 8 | 112 ± 4 | 109 ± 3 |
| DBP | 62 ± 7 | 62 ± 8 | 68 ± 7 | 61 ± 2 | 64 ± 5 | 63 ± 5 | 64 ± 9 | 64 ± 4 | 64 ± 4 | 64 ± 5 |
| HR | 71 ± 11 | 66 ± 5 | 70 ± 11 | 70 ± 8 | 68 ± 5 | 71 ± 10 | 71 ± 12 | 73 ± 7 | 72 ± 7 | 74 ± 11 |
| TP extract = 10 g | ||||||||||
| SBP | 110 ± 12 | 104 ± 6 | 98 ± 9 | 100 ± 8 | 104 ± 9 | 110 ± 9 | 112 ± 6 | 108 ± 9 | 111 ± 7 | 113 ± 11 |
| DBP | 65 ± 9 | 68 ± 10 | 64 ± 5 | 65 ± 5 | 62 ± 5 | 67 ± 10 | 67 ± 3 | 62 ± 6 | 64 ± 5 | 60 ± 3 |
| HR | 73 ± 5 | 66 ± 10 | 65 ± 6 | 67 ± 8 | 71 ± 6 | 76 ± 5 | 76 ± 3 | 79 ± 4 | 75 ± 5 | 80 ± 9 |
Data are Mean ± SD; n = 5 participants per dose level. No differences were observed between Day 1 (d1) 0 hours (0 h) and Day 5 (d5)_3 hours (3 h) analyzed using the Wilcoxon signed-rank test. TP, tomato pomace; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate.