PALM INTER group promotes adipocytes hypertrophy (I) and induces inflammatory cytokine expression (A,C). (I). Photomicrography of epididymal visceral adipose tissue dissected from LDLr-KO mice fed a high-fat diet enriched with polyunsaturated fatty acids (PUFA), palmitic acid (PALM), palmitic interesterified fat (PALM INTER), stearic acid (STEAR), and stearic interesterified fat (STEAR INTER) for 16 weeks. Sections were stained with hematoxylin eosin and photomicrography is presented under 20x objective lens. (II). Western blot analysis from Both stearic groups (STEAR and STEAR INTER groups) was not performed (A–D) because of the small amount of adipose tissue obtained in these groups. Data were checked for normality prior to statistical analysis. One-way ANOVA was performed, followed by the post hoc Newman–Keuls test. Statistically significant difference is presented by different letters (p < 0.05) with a > b > c values. Data are shown as mean ± SEM (n = 6).