Supplemental Figure S9.

Reduced sphingosine in the Asah1^P361R/P361R mice. Additional sphingolipids were measured in retinal lysates of both 3- to 4- and 8- to 9-week–old Asah1^+/+ and Asah1^P361R/P361R mice. A and B: Quantification of sphingosine in retinal lysates from 3- to 4-week–old (A) and 8- to 9-week–old (B) mice. C: Quantification of ceramide-1-phosphate in retinal lysates from 8- to 9-week–old mice. Sphingosine-1-phosphate was measured in retinal lysates from both age groups but was lower than the limit of detection. Data are expressed as means ± SEM. n = 5 to 6 animals for each genotype and age group. ^∗∗P < 0.01.