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. 2019 Feb;189(2):320–338. doi: 10.1016/j.ajpath.2018.10.018

Figure 1.

Figure 1

Anterior uveitis and optic nerve pathology in Asah1P361R/P361R mice. A and B: Slit-lamp images of the anterior section of 8- to 9-week–old control Asah1+/+ (A) and Asah1P361R/P361R (B) mice. Granulomatous keratic precipitates (white arrows) and Busacca and Koeppe nodules (black arrows) indicate inflammation of the anterior segment of the Asah1P361R/P361R eye with clusters of pigment on anterior lens capsule (white arrowheads). C and D: Confocal scanning laser ophthalmoscope imaging was performed on 8- to 9-week–old control Asah1+/+ (C) and Asah1P361R/P361R (D) mice for near-infrared reflectance (IR; 810 nm) and blue light autofluorescence (BAF; 486 nm; emission filter, 525/50 nm). Representative IR and BAF images of healthy retinas from Asah1+/+ mice showing no autofluorescence (C). Representative IR and BAF images from two Asah1P361R/P361R mice each with varying levels of reflectivity and autofluorescence permeating from the optic nerve (D).