Figure 11.

Altered sphingolipid species in the retina of Asah1^P361R/P361R mice. Sphingolipids were quantified in retinal tissue from Asah1^+/+ and Asah1^P361R/P361R mice by liquid chromatography–mass spectrometry. Quantification of ceramide (Cer; A), sphingomyelin (SM; B), and monohexosylceramide (MHC; C) species in retinal tissue from 3- to 4-week–old Asah1^+/+ mice and Asah1^P361R/P361R mice. The relative abundance of Cer (D), SM (E), and MHC (F) species in retinal tissue from 3- to 4-week–old Asah1^+/+ and Asah1^P361R/P361R mice. Quantification of Cer (G), SM (H), and MHC (I) species in retinal tissue from 8- to 9-week–old Asah1^+/+ and Asah1^P361R/P361R mice. The relative abundance of Cer (J), SM (K), and MHC (L) species in retinal tissue from 8- to 9-week–old Asah1^+/+ and Asah1^P361R/P361R mice. Data are expressed as means ± SEM. n = 5 to 6 animals for each genotype and age group. ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001.