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. 2019 Feb;189(2):320–338. doi: 10.1016/j.ajpath.2018.10.018

Figure 5.

Figure 5

Increased retinal thickness in Asah1P361R/P361R mice. A–D: Morphometric analyses of retinas from 3- to 4-week–old (A and C) and 8- to 9-week–old (B and D) control Asah1+/+ mice and test Asah1P361R/P361R mice from hematoxylin and eosin–stained sections. E–H: Retinal thickness plot generated from optical coherence tomography B-scans on samples from 3- to 4- and 8- to 9-week–old Asah1+/+ mice and Asah1P361R/P361R mice. Retinal thickness is significantly increased in the Asah1P361R/P361R mice when an n-way analysis of variance is performed for factors that included genotype, age, and retinal location. E and F:P < 0.0001. Data are expressed as means ± SEM (A–D) and means ± SD (E–H). n = 10 animals per group (A–D); n = 6 to 10 animals per group (E–H). ∗P < 0.05, ∗∗∗P < 0.001. GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer; IS, inner segment; NF, nerve fiber; ONH, optic nerve head; ONL, outer nuclear layer; OPL, outer plexiform layer; OS, outer segment; RPE, retinal pigment epithelium.