Figure 2.

Schematic drawing of varicella zoster virus (VZV) gE, gE_L, and gE_HP with an outline of the glycan compositions and positions on the peptide sequence of gE_HP as determined by mass spectrometry in the present study. Three O-linked glycan epitope clusters (GC) of sialylated core 1 O-linked glycans and one complex type N-linked glycan were found. Two O-linked glycans were situated within the linear B cell epitope (green) [29] while the largest cluster of O-linked glycans was found in the mucin-like domain (MLD) (yellow) close to the transmembrane domain (purple). For gE_HP, neither the IDE domain (red) nor the gI-binding domain (blue) contained any glycans, while O-linked glycans were found in the corresponding domains of gE_L [30].