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. 2019 Jan 7;40:432–445. doi: 10.1016/j.ebiom.2018.12.062

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© 2019 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Supplementary Fig. 4 — (a) The predicted circPTGR1–miRNA–mRNA interaction network, generated by Cytoscape. (b) circPTGR1 mRNA expression level in exosomes isolated from serum obtained from the in vivo metastasis model mice (hsa_circ_0088030: NC exo vs. PBS, P = .0102; sh exo vs. NC exo, P = .0043; hsa_circ_0003731: sh exo vs. NC exo, P = .0142; hsa_circ_0008043: NC exo vs. PBS, P = .0193; sh exo vs. NC exo, P = .0240). (c, d) MET expression levels in tissues from the in vivo metastasis model mice. (For miR449: NC exo vs. PBS, P = .0108; sh exo vs. NC exo, P = .0003. For MET: NC exo vs. PBS, P = .0230; sh exo vs. NC exo, P = .0163.) Scale bars: 100 μm. * P < .05 vs. PBS treatment. #P < .05 or ## P < .01 vs. NC group. (e) MET protein level in tissues from the in vivo metastasis model mice.