Table 1.
Comparison between right colon cancers with different ages of onset.
| RIGHT COLON | n/N EOCRC |
EARLY-ONSET n/Right-sided EOCC (%) | n/N LOCRC |
LATE-ONSET n/ Right-sided LOCC (%) |
p(χ2) |
|---|---|---|---|---|---|
| Number of cases (%) | 20/82 | 24% | 38/97 | 39% | |
| Age of Onset (mean (SD), years) 1 | - | 39.1 (6) | - | 79.08 (5) | NS |
| Gender | 10/82 | Female 10/20 (50%) | 25/97 | Female 25/38 (66%) | NS |
| Grade of tumor differentiation (%) 2 | 5/82 | Poor 5/20 (25%) | 24/97 | Medium 24/38 (63%) | NS |
| Mucosecretion2 | 7/82 | 7/20 (35%) | 13/97 | 13/38 (34%) | NS |
| Presence of “Signet-ring” cells 2 | 0/82 | 0/20 (0%) | 0/97 | 0/38 (0%) | NS |
| TNM (UICC) Stage (%) | 16/82 | I-II: 16/20 (80%) | 30/97 | II-III: 30/38 (79%) | NS |
| Associated Polyps | 7/82 | 14/20 (70%) | 19/97 | 24/38 (63%) | NS |
| Mean number of associated polyps 1 | - | 3 | - | 1.8 | 0.021 |
| Type of associated polyps (%) | 10/82 | Mixed: 10/20 (50%) | 21/97 | Adenomatous: 21/38 (54%) | NS |
| S- and/or MCRC | 4/82 | 4/20 (20%) | 9/97 | 9/38 (24%) | NS |
| Amsterdam criteria for LS | 8/82 | 8/20 (40%) | 1/97 | 1/38 (3%) | <0.001 |
| Familial aggregation for LS-related neoplasms | 7/82 | 7/20 (35%) | 6/97 | 6/38 (16%) | 0.008 |
| Familial aggregation for LS-unrelated neoplasms | 1/82 | 1/20 (5%) | 1/97 | 1/38 (3%) | NS |
| Sporadic cases | 4/82 | 4/20 (20%) | 28/97 | 28/38 (74%) | <0.001 |
| Disease-Free Survival (mean; months) 1 | - | 72.4 | - | 20.16 | 0.002 |
| Global Survival (mean; months) 1 | - | 81.06 | - | 45.94 | 0.003 |
| MSI | 6/82 | 6/20 (30%) | 7/38 | 7/38 (18%) | NS |
| MMR genes germline mutations | 6/82 | 6/20 (30%) | 5/97 | 5/ 38 (13%) | NS |
| BRAF mutation | 0/82 | 0/82 (0%) | 5/97 | 5/38 (13%) | NS |
| CIMP Classification (%) 2 | 0.025 | ||||
| High | 8/78 | 8/16 (50%) | 7/90 | 7/36 (20%) | |
| Low | 6/78 | 6/16 (37.5%) | 12/90 | 12/36 (33%) | |
| 0 | 2/78 | 2/16 (12.5%) | 17/90 | 17/36 (47%) | |
| Molecular Classification (%) 2 | |||||
| MSI-CIMP-High | 3/82 | 3/16 (19%) | 5/90 | 5/36 (14%) | 0.019 |
| MSI-CIMP0 | 2/82 | 2/16 (12.5%) | 2/90 | 2/36 (5%) | |
| MSS-CIMP-High | 5/82 | 5/16 (31%) | 2/90 | 2/36 (5%) | |
| MSS-CIMP0 | 6/82 | 6/16 (37.5%) | 27/90 | 27/36 (75%) | |
| Genomic instability1 | |||||
| GII Gain | 0.144296 | 0.183649 | NS | ||
| GII Loss | 0.058762 | 0.249820 | 0.003 | ||
| GII Normal | 0.796933 | 0.566522 | 0.03 | ||
| Mean Gained Chromosomes | 1.38 | 1.80 | NS | ||
| Mean Lost Chromosomes | 0.08 | 2.20 | 0.18 |
1 Statistical analysis was carried out using Student’s t-test. 2 It has been carried out on the maximum number of patients with the specimen available. EOCC: Early-onset colon cancer; EOCRC: Early-onset colorectal cancer; LOCC: Late-onset colon cancer: LOCRC: Late-onset colorectal cancer; NS: Not significant; SD: Standard deviation; UICC: International Union Against Cancer; S- and/or MCRC: synchronous and/or metachronous; LS: Lynch syndrome; MMR: Mismatch repair; MSI: Microsatellite instability; CIMP: CpG island methylator phenotype; MSS: Microsatellite stable; GII: Genomic instability index.