Table 2.

Summary of correlation between high MRN complex expression and favourable clinicopathological outcomes in colorectal cancer.

Ref.	Tumour Type	Sample Size	Molecule	Results
Ho 2017 [9]	Rectal	266	RAD50	Low RAD50 expression in TP was associated with subgroup needing adjuvant treatment
				Low RAD50 expression was associated with worse DFS and OS in low-grade tumour subgroup
				Low RAD50 expression in TC correlated with decrease DFS
Gao 2008 [43]	MSI colorectal; MSS colorectal	208 CRC 171 healthy mucosa 26 LN metastases	MRN complex	High MRN was associated with early tumour stage, MSS status and favourable survival
			MRE11	Higher MRE11 expression was observed in CRC cells compared to normal mucosa; and in MSS tumours, high MRE11 was associated with less local recurrence, high apoptotic activity and favourable survival
			NBS1	High NBS1 was associated with favourable survival in early tumour stage and in MSS tumours

TP, tumour periphery; MSS, microsatellite stable.