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Possible strategies for the preparation of mesoporous silica-containing composites for MRI detection. (A) SPIONS contained in IOMSNs enable T1 weighted MRI, while the outer mesoporous silica shell facilitates the development of hyperthermia-triggered systems. (B) Doping the silica matrix with acidic cleavable contrast cations for T1 weighted MRI. (C) Capping mesopores with doped SPIONs for favoring acidic release of T1 (SPIONs) and T2 (Mn2+) contrast agents.
