Table 1.
Observational studies on the relationship between serum 25-hydroxyvitamin D (25(OH)D) and initiation of osteoarthritis (OA) and related symptoms 1.
| Author {Reference} | n | Country (Cohort) | Follow-up (years) | Baseline 25(OH)D (nmol/L) | Results |
|---|---|---|---|---|---|
| Joint pain and function | |||||
| Laslett et al. [51] | 764 | Australia | 5 | 54 | Moderate 25(OH)D (12.5–25 nmol/L) predicted less increase in knee pain |
| Laslett et al. [51] | 765 | Australia | 2.4 | 54 | Moderate vitamin D status may predict change in hip pain |
| Radiographic OA | |||||
| Bergink et al. [47] | 1248 | Netherlands | 8.4 | 66 | No association |
| McAlindon et al. [48] | 556 | USA (Framingham Study) | 8 | 74 | No association |
| Felson et al. [49] | 277 | USA (BOKS) | 2.5 | 51 | No association |
| Felson et al. [49] | 715 | USA (Framingham Offspring) | 9.5 | 49 | No association |
| Lane et al. [50] | 237 | USA (SOF) | 8 | 66 | No association |
| Konstari et al. [51] | 805 | Finland | 22 | 113 | No association |
| Cartilage volume loss | |||||
| Ding et al. [46] | 353 | Australia (TASOAC) | 2.9 | 53 | No association |
1 BOKS: Boston Osteoarthritis of the Knee Study; SOF: Study of Osteoporotic Fractures; TASOAC: Tasmanian Older Adult Cohort.