Table 3.

Associations between maternal vitamin B₁₂ and folate status with infant serum vitamin B₁₂ concentrations.

			Univariate b		Multivariate c		Multivariate d
Maternal Variables	Time-Point	n	β (SE)	p-Value	β (SE)	p-Value	β (SE)	p-Value
Serum vitamin B12, a pmol/L	Mid-gestation	54	0.29 (0.17)	0.09	0.28 (0.16)	0.08	0.31 (0.16)	0.06
	Delivery (All)	64	0.85 (0.12)	<0.0001	0.74 (0.12)	<0.0001	0.77 (0.12)	<0.001
	Delivery (Recruited at mid-gestation)	33	0.57 (0.20)	0.004	0.53 (0.18)	0.003	0.53 (0.16)	0.001
	Delivery (Recruited at delivery)	31	1.09 (0.13)	<0.0001	0.97 (0.14)	<0.0001	1.02 (0.12)	<0.001
<148.0 pmol/L	Mid-gestation	54	n/a	n/a	n/a	n/a	n/a	n/a
	Delivery (All)	64	−0.65 (0.16)	<0.0001	−0.54 (0.14)	0.0002	−0.62 (0.15)	<0.0001
	Delivery (Recruited at mid-gestation)	33	−0.63 (0.22)	0.004	−0.60 (0.19)	0.002	−0.56 (0.18)	0.002
	Delivery (Recruited at delivery)	31	−0.72 (0.22)	0.001	−0.59 (0.22)	0.008	−0.67 (0.21)	0.002
<221.0 pmol/L	Mid-gestation	54	−0.16 (0.15)	0.28	−0.18 (0.14)	0.20	−0.18 (0.14)	0.21
	Delivery (All)	64	−0.42 (0.12)	0.0007	−0.30 (0.12)	0.01	−0.33 (0.12)	0.008
	Delivery (Recruited at mid-gestation)	33	−0.23 (0.17)	0.17	−0.19 (0.16)	0.22	−0.26 (0.15)	0.07
	Delivery (Recruited at delivery)	31	−0.61 (0.17)	0.0004	−0.44 (0.17)	0.01	−0.41 (0.19)	0.03
Serum folate a, nmol/L	Mid-gestation	53	−0.24 (0.14)	0.09	−0.24 (0.14)	0.09	−0.28 (0.15)	0.06
	Delivery (All)	64	0.12 (0.16)	0.47	0.07 (0.16)	0.68	0.09 (0.17)	0.61
	Delivery (Recruited at mid-gestation)	33	0.09 (0.22)	0.69	0.12 (0.23)	0.60	0.16 (0.26)	0.54
	Delivery (Recruited at delivery)	31	0.12 (0.25)	0.63	0.06 (0.23)	0.81	0.11 (0.22)	0.62
<40.0 nmol/L	Mid-gestation	53	0.10 (0.12)	0.40	0.11 (0.12)	0.37	0.14 (0.13)	0.28
	Delivery (All)	64	−0.06 (0.13)	0.65	0.02 (0.13)	0.87	0.02 (0.13)	0.88
	Delivery (Recruited at mid-gestation)	33	−0.05 (0.17)	0.76	−0.08 (0.17)	0.64	0.04 (0.20)	0.86
	Delivery (Recruited at delivery)	31	−0.08 (0.21)	0.69	0.11 (0.18)	0.56	0.15 (0.17)	0.39

^a Statistical analyses: Linear regression models were used to examine associations between maternal vitamin B₁₂ and folate status and infant serum vitamin B₁₂ concentrations; vitamin B₁₂ and folate concentrations were natural logarithmically transformed prior to analyses; ^b Adjusted for gestational age of sample collection; ^c Adjusted for gestational age of sample collection, maternal age at delivery, parity (≥1 vs. 0), ever smoked (yes vs. no), relationship status (single vs. married/in a relationship), self-reported prenatal supplement use (≥2 vs. <2 pills/week), pre-pregnancy BMI, and race (African American vs. other); ^d Adjusted for gestational age of sample collection, maternal age at delivery, parity (≥1 vs. 0), ever smoked (yes vs. no), relationship status (single vs. married/in a relationship), self-reported prenatal supplement use (≥2 vs. <2 pills/week), pre-pregnancy BMI, race (African American vs. other), intake of vitamin B₁₂, and intake of folate.