Table 2.
Summary of association of molecular subtypes with response to NAC based on the published studies.
| Ref | Molecular Subtype | Patients (n) | Definition of Response | Response Number (%) | p-Value |
|---|---|---|---|---|---|
| [60] Discovery |
Basal Luminal P53-like |
5 6 7 |
pT0 or pT1 | 2 (40%) 4 (67%) 0 (0) |
0.018 |
| [60] Philadelphia Validation |
Basal Luminal P53-like |
14 20 9 |
pT0 or pT1 | 7 (50%) 12 (60%) 1 (11%) |
- |
| [61] | Basal Luminal P53-like |
11 11 16 |
≤pT1N0M0 | 5 (45%) 8 (73%) 5 (31%) |
- |
| [62] 1 | Claudin-low Basal Luminal-infiltrated Luminal |
57 68 33 111 |
≤pT1N0M0 | 23 (40%) 28 (41%) 9 (27%) 48 (43%) |
NS |
1 Basal and luminal-infiltrated tumors who showed a response unfortunately did not have an improved survival. Claudin-low and luminal tumor subtypes did show an improved overall survival. NS: non-significant