Figure 24.
Equilibrium air-water surface tensions for lung surfactants in Tris buffer (pH 7) at 37 °C. The data include 1 mg/mL suspensions of three different commercialised lung surfactants and extracted native surfactant (NS) from porcine lungs and the measurement of a synthetic lung surfactant formulation: 4% Super Mini-B (SMB) lung surfactant protein peptide in a phospholipid mixture (PL = DPPC:POPC:POPG 50:30:20 molar ratio), and the pure SMB peptide itself. (a) Equilibrium surface tension plot from the applied pressure vs. 2/Rc plot. The surface tension for each sample are shown in the legend derived as usual form linear fitting of the slopes. (b) Dynamic surface tension change of each sample by using the first-generation area expansion method developed by Lee et al. [9]. The symbols correspond between these two graphs. With permission from American Chemical Society [10].