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Arsenic trioxide (ATO) enhances gemcitabine (GEM)-induced apoptotic cell death. Patu8988 and Panc-1 cells were treated either with 3 µM ATO or 20 µM GEM, or a combination of both drugs for 48 h. Apoptotic cells were detected by annexin V/PI staining as described in the Materials and Methods. Both: ATO plus GEM.
