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The effect of arsenic trioxide (ATO) and gemcitabine (GEM) on the expression of Skp2. (A) The expression of Skp2, and its downstream proteins, p21 and p57, were measured by western blotting of Patu8988 and Panc-1 cells treated with either 3 µM ATO or 20 µM GEM, or a combination of the two drugs for 48 h. (B) The quantitative results are illustrated in (A). *P < 0.05 compared with the control; #P < 0.05 compared with ATO alone or GEM alone. Both: ATO plus GEM.
