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Dot1L knockout promote Wnt signaling pathway. A. The activity of Wnt/β-catenin signaling pathway was assessed by dual-luciferase reporter assays in control and Dot1L knockout cells (n=3). B. The expression of total and activated β-catenin (non-phosphorylation status) was detected by western blotting in control or Dot1L knockout OVCAR3 and OVCAR4 cells.
