Figure 5.

Quercetin elicited obvious ERS and selectively activated the IRE1α branch in hypoxic rat PASMCs. A. Immunofluorescence staining was performed to analyze the expression of GRP78 after quercetin treatment. B, C. The levels of UPR sensors were quantified by Western blots in PASMCs treated with quercetin and hypoxia for 48 h, the representative bands and protein quantifications are shown. Qu, quercetin. Data are shown as the mean ± SEM; n = 4. *P < 0.05, **P < 0.01 compared with normoxia group; ^#P < 0.05, ^##P < 0.01 compared with hypoxia.